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| "U" Player Index | |
| Starts with "U" Career Batting Register
and Career Pitching Register Bold indicates a Hall of Famer. |
| Ubel, Doktor | 2009-2017 |
| Ucelay, Matthew | 2027-2030 |
| Ugueto, Luis | 2003-2014 |
| Uhl, Steven | 2023-2031 |
| Ukon, Motojirou | 2033-2033 |
| Ulacia, Dennis | 2010-2014 |
| Ulrey, Derrick | 2015-2028 |
| Umgabu, Umga | 2008-2015 |
| Unzueta, Steven | 2032-2033 |
| Upton, B.J. | 2009-2020 |
| Urbina, Ugueth | 1996-2011 |
| Urdaneta, Lino | 2005-2010 |
| Urena, Fabian | 2015-2015 |
| Urena, Manny | 2031-2033 |
| Uribe, Juan | 2002-2013 |
| Urich, Harold | 2027-2033 |
| Urrutia, Hong | 2024-2031 |
| Usher, Scott | 2025-2031 |
| Utley, Chase | 2003-2017 |
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